It is well established that nuclear quantum effects (NQEs) can significantly impact the structure and reactivity of molecules containing light nuclei, yet their influence on real space chemical bonding descriptors remains largely unexplored. In this study, we present the first systematic analysis of how NQEs modify robust quantum chemical topology (QCT) indicators derived from the electronic density. Using nuclear-electronic orbital density functional theory (NEO-DFT), we treat selected protons quantum mechanically and analyze the resulting self-consistent electronic and protonic densities within the framework of the quantum theory of atoms in molecules. A diverse set of molecular systems spanning hydridic to protic hydrogen environments is investigated. We show that proton delocalization induces a characteristic, non-spherical depletion of the electronic density around the classical nuclear position, leading to systematic changes in atomic charges, bonded radii, delocalization indices